Description

[1R-[1(2S*,5R*),2Beta,5Alpha]]-5-(4-Amino-5-Fluoro-2-Oxo-1(2H)-Pyrimidinyl)-1,3-Oxathiolane-2-Carboxylic Acid 5-Methyl-2-(1-Methylethyl)Cyclohexyl Ester is a chemically sophisticated nucleoside analogue derivative, designed for high-purity research and development applications. This compound is critical for pharmaceutical development, particularly in the synthesis and study of antiviral agents, due to its specific stereochemistry and functional groups. It serves as a vital building block for medicinal chemists and researchers in advanced drug discovery programs targeting viral diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel antiviral drugs, particularly nucleoside reverse transcriptase inhibitors (NRTIs).
• Active Pharmaceutical Ingredient (API) Development: Used in the synthesis and process optimization of potential active pharmaceutical ingredients for clinical studies.
• Biochemical Research: Employed as a reference standard or probe in enzymatic studies and mechanism-of-action research for virology.
• Process Chemistry: Serves as a critical intermediate in scaling up synthetic routes for complex therapeutic molecules under GMP conditions.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in medicinal chemistry and organic synthesis.

Basic Information

Product Name	[1R-[1(2S*,5R*),2Beta,5Alpha]]-5-(4-Amino-5-Fluoro-2-Oxo-1(2H)-Pyrimidinyl)-1,3-Oxathiolane-2-Carboxylic Acid 5-Methyl-2-(1-Methylethyl)Cyclohexyl Ester
CAS No.	147126-75-8
Molecular Formula	C20H28FN3O5S
Molecular Weight	441.52 g/mol
Synonyms	5-Fluoro-1-[(2S,5R)-2-[(1S,2R,5S)-5-Methyl-2-(1-methylethyl)cyclohexyloxycarbonyl]-1,3-oxathiolan-5-yl]cytosine; L-OddC Diol Derivative; 5-Fluoro-L-OddC Cyclohexyl Ester; (2'R,5'S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine Cyclohexyl Ester Derivative; β-L-5-Fluorocytosine Oxathiolane Nucleoside Ester; Antiviral Nucleoside Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [1R-[1(2S*,5R*),2Beta,5Alpha]]-5-(4-Amino-5-Fluoro-2-Oxo-1(2H)-Pyrimidinyl)-1,3-Oxathiolane-2-Carboxylic Acid 5-Methyl-2-(1-Methylethyl)Cyclohexyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.