Description

Laflunimus is a synthetic, small-molecule pharmaceutical compound with significant immunomodulatory properties. Its primary value lies in its targeted mechanism of action, which makes it a key intermediate in the research and development of novel therapeutic agents. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers focused on developing treatments for autoimmune and inflammatory conditions. We supply high-purity Laflunimus CAS NO 147076-36-6 to support critical drug discovery and process development efforts globally.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) for immunology.
• Drug Discovery Research: Used as a reference standard and a key compound in preclinical studies investigating immunosuppressive pathways.
• Biochemical Research: Employed in in vitro assays to study T-cell activation, cytokine modulation, and other immune system functions.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for new drug candidates in pilot plants.
• Academic Research: A valuable tool for universities and research institutes exploring novel mechanisms in autoimmunity and inflammation.
• GMP Manufacturing: Supplied under controlled conditions for use in the production of clinical trial materials.

Basic Information

Product Name	Laflunimus
CAS No.	147076-36-6
Molecular Formula	C₁₇H₁₄F₆N₄O₃
Molecular Weight	460.31 g/mol
Synonyms	N-[4-(Trifluoromethyl)phenyl]-5-methylisoxazole-4-carboxamide, 3-[(3,5-Bis(trifluoromethyl)phenyl)amino]-5-methylisoxazole-4-carboxylic acid phenylamide, LFM-A13, BMS-345541 (related analog), Leflunomide metabolite analog, Immunosuppressive isoxazole derivative
EINECS	Contact for details

Quality Control

Every batch of Laflunimus is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay purity, related substances, and residual solvents. Our quality standards are designed to meet the rigorous demands of preclinical and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.