Description

2',3'-Dideoxy-β-5-Fluorocytidine CAS NO 147058-39-7 is a fluorinated nucleoside analog, a key intermediate in the synthesis of antiviral and anticancer pharmaceuticals. Its modified sugar and nucleobase structure is critical for developing potent therapeutic agents that target viral replication and cellular proliferation. This high-purity compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical suppliers engaged in the synthesis of next-generation antiviral drugs and oncology treatments.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in R&D for developing therapeutics targeting viruses such as HIV, hepatitis, and other retroviruses.
• Oncology Research: Serves as a precursor for chemotherapeutic agents designed to inhibit cancer cell growth.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleic acid metabolism and polymerase activity.
• Process Development: Utilized in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2',3'-Dideoxy-β-5-Fluorocytidine
CAS No.	147058-39-7
Molecular Formula	C9H11FN3O3
Molecular Weight	228.20 g/mol
Synonyms	5-Fluoro-2',3'-dideoxycytidine; 5-Fluoro-ddC; 5-Fluoro-2',3'-dideoxycytidine; β-5-Fluoro-2',3'-dideoxycytidine; 1-((2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-1,2-dihydropyrimidine-2,4-dione; 5-Fluoro-1-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; NSC 669234
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-β-5-Fluorocytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.