Description

(((1R)-2-(2,6-Diamino-9H-Purin-9-Yl)-1-Methylethoxy)Methyl)Phosphonic Acid CAS NO 147057-10-1 is a high-purity nucleoside phosphonate derivative, a key building block in advanced pharmaceutical research and development. This compound is valued for its role as a potent and selective inhibitor of specific enzymatic pathways, offering significant potential in therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of nucleotide analog prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Research: Investigated as a key component in the development of novel therapeutics targeting viral polymerases and reverse transcriptases.
• Oncology Drug Discovery: Used in research programs focused on creating targeted therapies that interfere with DNA synthesis and cell proliferation in cancer cells.
• Biochemical Tool Compound: Employed in enzymatic assays and mechanistic studies to understand purine metabolism and nucleotide-related pathways.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• GMP Manufacturing: Supplied as a high-quality starting material for cGMP-compliant production processes in regulated pharmaceutical manufacturing.

Basic Information

Product Name	(((1R)-2-(2,6-Diamino-9H-Purin-9-Yl)-1-Methylethoxy)Methyl)Phosphonic Acid
CAS No.	147057-10-1
Molecular Formula	C11H18N6O4P
Molecular Weight	329.27 g/mol
Synonyms	(1R)-2-(2,6-Diamino-9H-purin-9-yl)-1-methylethoxymethylphosphonic Acid; (R)-PMPA Intermediate; (R)-9-[2-(Phosphonomethoxy)propyl]adenine Intermediate; (R)-PMPA Precursor; GS-7340 Intermediate; Tenofovir Alafenamide (TAF) Related Compound; Adenine, 9-[(1R)-2-[[(phosphonomethyl)oxy]methyl]propyl]-2,6-diamino-; Adefovir Related Compound
EINECS	Contact for details

Quality Control

Our (((1R)-2-(2,6-Diamino-9H-Purin-9-Yl)-1-Methylethoxy)Methyl)Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification and impurity profiling. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.