Description

(S)-1-(Diphenylphosphino)-3-Phenylpropan-2-Amine is a chiral, bidentate P,N-ligand widely used in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of optically pure intermediates. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in their synthetic processes.

Application

• As a key ligand in asymmetric hydrogenation reactions for the synthesis of chiral amino acids and pharmaceutical intermediates.
• Catalyst component for asymmetric C-C bond-forming reactions, including allylic alkylation and hydroformylation.
• Used in the preparation of chiral catalysts for academic research and process development in organic synthesis.
• Employed in the synthesis of optically active natural products and complex molecules.
• Critical for developing stereoselective manufacturing routes for active pharmaceutical ingredients (APIs).
• Application in asymmetric transfer hydrogenation processes.

Basic Information

Product Name	(S)-1-(Diphenylphosphino)-3-Phenylpropan-2-Amine
CAS No.	146476-38-2
Molecular Formula	C21H22NP
Molecular Weight	319.38 g/mol
Synonyms	(S)-1-(Diphenylphosphino)-2-amino-3-phenylpropane; (S)-2-Amino-1-(diphenylphosphino)-3-phenylpropane; (S)-1-(Diphenylphosphino)-3-phenyl-2-propylamine; (S)-DPPAP; (S)-P,N Ligand; (S)-Phenylpropan-2-amine, 1-(diphenylphosphino)-; (S)-1-(Diphenylphosphino)-3-phenylpropan-2-amine
EINECS	Contact for details

Quality Control

Our (S)-1-(Diphenylphosphino)-3-Phenylpropan-2-Amine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced catalytic applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should be kept sealed when not in use to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.