Description

1-o-Hexadecyl-2-Hydroxypropane-3-Phosphonocholine is a synthetic phospholipid derivative, specifically a phosphonocholine analog, known for its unique structural and functional properties. This compound is valued for its role as a key intermediate and functional component in advanced material science and biomedical research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and specialty chemical sectors. Its specific structure makes it suitable for applications requiring precise membrane interactions and chemical modifications.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical component in the development of non-viral delivery systems for mRNA vaccines and therapeutics.
• Biomimetic Membrane Research: Used to create model cell membranes (liposomes, vesicles) for studying membrane protein function, permeability, and fusion events.
• Drug Delivery Systems: Serves as a functional excipient or conjugate in targeted drug delivery platforms to enhance cellular uptake and stability.
• Bioconjugation & Probe Synthesis: Acts as a chemical handle or precursor for synthesizing fluorescent or affinity-tagged phospholipid probes for diagnostic assays.
• Surface Modification: Employed to create biocompatible coatings on medical devices or sensor surfaces to reduce non-specific binding.
• Biophysical Studies: Utilized in calorimetry (DSC) and spectroscopy studies to investigate lipid bilayer properties, phase behavior, and interactions with other molecules.

Basic Information

Product Name	1-o-Hexadecyl-2-Hydroxypropane-3-Phosphonocholine
CAS No.	146403-33-0
Molecular Formula	C24H52NO5P
Molecular Weight	465.65 g/mol
Synonyms	Hexadecylphosphonocholine; D-erythro-Hexadecylphosphonocholine; PC-C16(P); 1-Hexadecyl-2-hydroxy-3-(phosphonocholine)propane; Miltefosine Impurity; Phospholipid C16; 1-O-Hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine analog; C16 Phosphonocholine
EINECS	Contact for details

Quality Control

Our 1-o-Hexadecyl-2-Hydroxypropane-3-Phosphonocholine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry. We ensure compliance with high-purity standards suitable for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.