Description

Dihydronodularin is a reduced form of the potent cyanobacterial hepatotoxin nodularin, a cyclic pentapeptide. This compound is of significant interest in biochemical and toxicological research for studying the structure-activity relationships and metabolic pathways of nodularin-class toxins. It serves as a critical reference standard and research tool for scientists in environmental monitoring, toxicology, and marine biotoxin research, aiding in the development of detection methods and understanding toxin mechanisms.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of nodularin variants in environmental and laboratory samples.
• Toxicology Studies: Employed in in vitro and in vivo research to investigate the comparative toxicity, metabolic detoxification, and biological effects of reduced nodularin congeners.
• Analytical Method Development: Serves as a critical calibrant and control in developing and validating advanced analytical techniques such as LC-MS/MS, HPLC, and ELISA for cyanotoxin detection.
• Environmental Monitoring: Acts as a key analyte in monitoring programs for cyanobacterial blooms in freshwater and marine ecosystems to assess public health risks.
• Enzyme Inhibition Studies: Utilized to study the inhibition of protein phosphatases (e.g., PP1 and PP2A), providing insights into cellular signaling pathways disrupted by hepatotoxins.

Basic Information

Product Name	Dihydronodularin
CAS No.	146109-35-5
Molecular Formula	C₄₁H₆₅N₈O₁₀
Molecular Weight	829.99 g/mol
Synonyms	Dihydro-nodularin; [D-Asp³]nodularin; Nodularin variant; Cyclic([(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]-D-γ-glutamyl-(2S)-2-methylbutyryl-L-arginyl-D-asparaginyl-(2Z,4S)-2-(aminomethylidene)-4-methyl-5-oxopentanoyl); Cyanobacterial hepatotoxin derivative
EINECS	Contact for details

Quality Control

Our Dihydronodularin is produced and handled under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for reference standard materials to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the sealed container to reach room temperature before opening to prevent condensation. The material should be stored in a cool, dry, and well-ventilated area dedicated for the storage of research chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.