Description

Troxacitabine CAS NO 145918-75-8 is a synthetic nucleoside analogue with potent antineoplastic activity, representing a significant advancement in cytarabine-related chemotherapeutics. Its unique L-configuration confers resistance to deamination, enhancing its metabolic stability and therapeutic potential in challenging oncology cases. This compound is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel treatments for hematologic malignancies and solid tumors.

Application

• Oncological Research & Drug Development: Serves as a key active pharmaceutical ingredient (API) and a critical reference standard in the discovery and preclinical evaluation of new anticancer agents.
• Biochemical Studies: Used as a substrate or inhibitor in enzymatic assays to study DNA synthesis, repair mechanisms, and nucleoside metabolism pathways.
• Pharmaceutical Intermediates: Acts as a sophisticated building block for the synthesis of more complex nucleoside-based prodrugs or targeted therapies.
• Clinical Research Material: Supplied as a high-purity compound for formulation studies, stability testing, and other investigational new drug (IND)-enabling activities.

Basic Information

Product Name	Troxacitabine
CAS No.	145918-75-8
Molecular Formula	C11H14FN3O5
Molecular Weight	287.25 g/mol
Synonyms	(-)-Troxacitabine; L-OddC; BCH-4556; Troxatyl; β-L-Dioxolane-cytidine; 1-(2-Deoxy-2-fluoro-β-L-lyxofuranosyl)cytosine; 2'-Deoxy-2'-fluoro-β-L-cytidine; L-2'-Fluoro-2'-deoxycytidine
EINECS	Contact for details

Quality Control

Our Troxacitabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the L-configuration, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider conditions under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.