Description

[[[(2R,5S)-5-(4-Amino-5-Fluoro-2,6-Dioxo-3H-Pyrimidin-1-Yl)-1,3-Oxathiolan-2-Yl]Methyl-Hydroxy-Phosphoryl]Oxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid is a high-purity, complex nucleotide analog with significant pharmaceutical relevance. This compound is valued for its role as a key intermediate in the synthesis of advanced antiviral and anticancer therapeutics. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Antiviral Drug Research: Used in the research and development of treatments for viral infections such as HIV, hepatitis B, and cytomegalovirus.
• Oncology Research: Serves as a precursor in the development of nucleoside analogs targeting cancer cell proliferation.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor in biochemical assays to study nucleotide metabolism.
• Process Development: Utilized by process chemists for scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	[[[(2R,5S)-5-(4-Amino-5-Fluoro-2,6-Dioxo-3H-Pyrimidin-1-Yl)-1,3-Oxathiolan-2-Yl]Methyl-Hydroxy-Phosphoryl]Oxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid
CAS No.	145819-92-7
Molecular Formula	C9H13FN3O12P3S
Molecular Weight	523.16 g/mol
Synonyms	1-[(2R,5S)-5-(4-Amino-5-fluoro-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen (hydroxyphosphonooxy)phosphonate; 5'-H-Phosphonato-5-fluoro-2'-deoxy-3'-thiacytidine; FTC 5'-(P-alpha,P-γ-Di)triphosphate; Emtricitabine 5'-Triphosphate Analog; β-L-(-)-FTC-TP; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development purposes. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.