Description

4-(3-Trifluoromethyl-Phenyl)-Butyric Acid is a versatile fluorinated aromatic carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the lipophilic trifluoromethyl group and a flexible butyric acid chain, which is instrumental for modifying the physicochemical properties of target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the CF₃ group improves lipophilicity and rainfastness.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens in high-performance display technologies.
• Polymer Modification: Incorporated as a monomer or chain terminator to create specialty polymers with tailored surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in coupling reactions (e.g., amidation, esterification) to introduce a fluorinated phenyl moiety into complex molecular architectures.
• Material Science Research: Utilized in the development of novel organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(3-Trifluoromethyl-Phenyl)-Butyric Acid
CAS No.	145485-43-4
Molecular Formula	C₁₁H₁₁F₃O₂
Molecular Weight	232.20 g/mol
Synonyms	4-[3-(Trifluoromethyl)phenyl]butanoic Acid; 3-(Trifluoromethyl)benzenebutanoic Acid; γ-(3-Trifluoromethylphenyl)butyric Acid; 4-(3-Trifluoromethylphenyl)butyric Acid; 4-(m-Trifluoromethylphenyl)butyric Acid; Butanoic acid, 4-[3-(trifluoromethyl)phenyl]-; 145485-43-4 (CAS)
EINECS	Contact for details

Quality Control

Our production of 4-(3-Trifluoromethyl-Phenyl)-Butyric Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis, to ensure consistency and reliability. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.