Description

(R)-Tetrahydro-1,3,3-Triphenyl-1H,3H-Pyrrolo[1,2-C][1,3,2]Oxaborole, 99% (R)-Phenyl Oxazaborolidine is a high-purity, chiral oxazaborolidine catalyst essential for achieving high enantioselectivity in organic synthesis. This compound is a cornerstone in asymmetric reduction and cycloaddition reactions, enabling the production of single-enantiomer intermediates with critical precision. It is primarily needed by research institutions and pharmaceutical manufacturers developing advanced active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals where stereochemical control is paramount.

Application

• Asymmetric Catalysis: As a chiral Lewis acid catalyst for enantioselective Diels-Alder, aldol, and reduction reactions.
• Pharmaceutical Intermediate Synthesis: For the production of chiral drug candidates and active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Agrochemical Research: In the development of enantiomerically pure herbicides, fungicides, and pesticides.
• Fine Chemical Manufacturing: For synthesizing chiral ligands, flavors, fragrances, and advanced material precursors.
• Academic & Process Chemistry: A valuable tool in methodological research and scale-up process development for asymmetric transformations.
• Borane-Mediated Reductions: Catalyzing the enantioselective reduction of prochiral ketones to secondary alcohols.

Basic Information

Product Name	(R)-Tetrahydro-1,3,3-Triphenyl-1H,3H-Pyrrolo[1,2-C][1,3,2]Oxaborole, 99% (R)-Phenyl Oxazaborolidine
CAS No.	145238-45-5
Molecular Formula	C23H21BNO
Molecular Weight	338.23 g/mol
Synonyms	(R)-1,3,3-Triphenyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole; (R)-Phenyl Oxazaborolidine; (R)-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; (R)-Triphenyl Oxazaborolidine; Corey's (R)-Oxazaborolidine Catalyst; (R)-2,3,4,5-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole; (R)-CBS Catalyst; (R)-1,3,3-Triphenyl-3-bora-2,4-diazacyclopent-4-ene 1-oxide
EINECS	Contact for details

Quality Control

Our (R)-Phenyl Oxazaborolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral analysis, to ensure the ≥99% purity and high enantiomeric excess meet the stringent requirements for catalytic applications. Certificates of Analysis (COA) with full characterization data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.