Description

n-(tert-Butoxycarbonyl)Glycine-2-13C is a stable isotope-labeled derivative of the amino acid glycine, where the carbon at the 2-position is enriched with the 13C isotope. This compound is a critical building block in the synthesis of isotopically labeled peptides and proteins for advanced research applications, providing a non-radioactive tracer for metabolic and pharmacokinetic studies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require high-purity, isotopically labeled intermediates for mass spectrometry, NMR spectroscopy, and drug discovery.

Application

• Isotope-Labeled Peptide Synthesis: Serves as a key protected amino acid precursor for the solid-phase and solution-phase synthesis of 13C-labeled peptides for structural biology and biophysical studies.
• Metabolic Pathway Tracing: Used to synthesize tracer molecules for investigating glycine metabolism, one-carbon metabolism, and related biochemical pathways in vitro and in vivo.
• Mass Spectrometry Standards: Employed as an internal standard in quantitative LC-MS/MS and GC-MS analyses to ensure accuracy and precision in bioanalytical assays for drug development.
• NMR Spectroscopy: Provides a 13C-enriched probe for nuclear magnetic resonance studies, enabling detailed structural and dynamic analysis of proteins and other biomolecules.
• Pharmaceutical Research: Integral to the development and characterization of new drug candidates, particularly those targeting metabolic diseases or requiring detailed ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.
• Proteomics Research: Used in the preparation of isotopically labeled protein standards for quantitative proteomics, enabling precise measurement of protein expression levels.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)Glycine-2-13C
CAS No.	145143-02-8
Molecular Formula	C7H1313CNO4
Molecular Weight	190.17 g/mol (for 13C1 isotopologue)
Synonyms	Boc-Glycine-2-13C; N-Boc-Glycine-2-13C; (tert-Butoxycarbonyl)glycine-2-13C; 2-((tert-Butoxycarbonyl)amino)acetic-2-13C acid; N-(tert-Butoxycarbonyl)-glycine-2-13C; Boc-Gly-OH-2-13C; 13C Labeled Boc-Glycine; Glycine-2-13C, N-Boc-protected
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)Glycine-2-13C is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment, chemical purity, and identity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic purity, and impurity profiles to ensure compliance with research and development standards. Our quality commitment supports traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.