Description

13C C16 Sphingomyelin (D18:1/16:0) is a stable isotope-labeled sphingolipid, specifically incorporating a 13C atom at the C16 position of the palmitoyl chain. This compound is essential as an internal standard for the precise quantification of endogenous sphingomyelin species in complex biological matrices using mass spectrometry. It is a critical reagent for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors, enabling accurate lipidomic profiling and biomarker discovery. The product is supplied with full analytical characterization to ensure reliability and traceability.

Application

• Mass Spectrometry Internal Standard: Primary use for the absolute quantification of natural sphingomyelin (D18:1/16:0) in lipidomics research.
• Biomedical Research: Investigation of sphingolipid metabolism, cell membrane structure, and signaling pathways in disease models (e.g., cancer, neurodegenerative disorders).
• Drug Discovery & Development: Used in pharmacokinetic and pharmacodynamic studies to track lipid-based drug candidates and their metabolites.
• Clinical Diagnostics: Development and calibration of assays for measuring sphingomyelin as a potential biomarker in plasma or tissue samples.
• Quality Control & Method Validation: Essential for validating analytical methods in contract research organizations (CROs) and pharmaceutical QC labs.
• Nutritional Science: Studies on the bioavailability and metabolic fate of dietary sphingolipids.

Basic Information

Product Name	13C C16 Sphingomyelin (D18:1/16:0)
CAS No.	144236-99-7
Molecular Formula	C39H7813CN2O6P
Molecular Weight	~ 732.0 g/mol (with 13C)
Synonyms	N-(13C-Palmitoyl)-sphingosine-1-phosphocholine; SM(d18:1/16:0-13C); (2S,3R,4E)-2-[(1-Hydroxy-13C-hexadecanoyl)amino]-4-octadecene-1,3-diol 1-(Dihydrogen Phosphate) 2-(Trimethylammonio)ethyl Ester; 13C-Labeled Sphingomyelin; 13C16-SM; D-erythro-Sphingosine, N-[(1-oxo-13C-hexadecyl)]-, 1-phosphocholine; Isotopically Labeled Sphingomyelin.
EINECS	Contact for details

Quality Control

Every batch of 13C C16 Sphingomyelin (D18:1/16:0) is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for quantitative mass spectrometry. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from NMR, HPLC, and mass spectrometry. Our quality commitment supports compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (TLC)	Single spot
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.