Description

2',3'-Dideoxy-5-Fluoro-3'-Thiauridine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics. The compound, identified by CAS number 143790-05-0, represents a critical building block for advancing medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of experimental antiviral drugs, especially those targeting HIV, hepatitis, and other viral infections.
• Anticancer Agent Research: Used in the development and study of nucleoside analogs designed to inhibit cancer cell proliferation.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide metabolism.
• Medicinal Chemistry: Acts as a scaffold for structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic candidates.
• Process Development: Utilized in scaling up synthetic routes for the GMP production of active pharmaceutical ingredients (APIs).
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2',3'-Dideoxy-5-Fluoro-3'-Thiauridine
CAS No.	143790-05-0
Molecular Formula	C9H11FN2O4S
Molecular Weight	262.26 g/mol
Synonyms	5-Fluoro-2',3'-dideoxy-3'-thiauridine; 5-Fluoro-3'-thia-2',3'-dideoxyuridine; 1-[(2R,5S)-5-(Hydroxymethyl)-1,3-oxathiolan-2-yl]-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Fluoro-dd-3'-Thiouridine; 5-Fluoro-3'-thia-2',3'-dideoxyuridine; 2',3'-Dideoxy-5-fluoro-3'-thiouridine; 5-Fluoro-3TC precursor; F-dd-3'-Thiouridine
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-5-Fluoro-3'-Thiauridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide Certificates of Analysis (COA) with detailed specifications for traceability and quality assurance. Our commitment ensures the material meets the high standards required for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant use and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.