Description

Benzoic Acid, 4-[1-(Aminocarbonyl)Cyclopropyl]-2,3,5-Trifluoro- is a high-value, multi-fluorinated benzoic acid derivative featuring a cyclopropane carboxamide substituent. This compound is a critical advanced pharmaceutical intermediate (API) designed for the synthesis of complex active ingredients, particularly in life sciences research and development. It is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise, high-purity building blocks for novel drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms and rigid cyclopropyl group enhance biological activity and environmental stability.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery for constructing molecules with improved pharmacokinetic properties and target binding affinity.
• Fluorinated Compound Library Building: Essential for creating specialized screening libraries in high-throughput discovery programs within biotechnology firms.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of fluorinated fine chemicals.
• Contract Research & Manufacturing (CRO/CMO): A critical raw material for organizations providing custom synthesis and process development services.

Basic Information

Product Name	Benzoic Acid, 4-[1-(Aminocarbonyl)Cyclopropyl]-2,3,5-Trifluoro-
CAS No.	143785-84-6
Molecular Formula	C11H9F3NO3
Molecular Weight	260.19 g/mol
Synonyms	2,3,5-Trifluoro-4-(1-carbamoylcyclopropyl)benzoic acid; 4-(1-Carbamoylcyclopropyl)-2,3,5-trifluorobenzoic acid; 1-Carbamoylcyclopropane-1-carboxylic acid, 2,3,5-Trifluoro- derivative; 4-(Aminocarbonylcyclopropyl)-2,3,5-trifluorobenzoic Acid; Cyclopropanecarboxamide, 1-(3,4,6-Trifluoro-2-carboxyphenyl)-; (1-(3,4,6-Trifluoro-2-carboxyphenyl)cyclopropyl)carboxamide
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-[1-(Aminocarbonyl)Cyclopropyl]-2,3,5-Trifluoro- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for each shipment, and we support compliance with REACH, FDA guidelines, and ICH Q7 for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizers, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.