Description

Cholest-5-En-3-Ol, 3-(6-(((2-Cyanoethoxy)(Diisopropylamino)Phosphino)Oxy)Hexyl)Carbamate is a high-purity, functionalized cholesterol derivative designed for advanced chemical synthesis. This compound is a critical building block in the development of novel lipid-based delivery systems and biomaterials, offering a reactive phosphoramidite group for controlled conjugation. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise molecular scaffolds for drug delivery, gene therapy, and nanotechnology applications.

Application

• Lipid Nanoparticle (LNP) Synthesis: A key intermediate for constructing ionizable or functionalized lipids used in mRNA and siRNA delivery systems.
• Bioconjugation Chemistry: Serves as a versatile linker for attaching therapeutic agents, targeting moieties, or imaging probes to cholesterol anchors.
• Biomimetic Membrane Research: Used to create modified liposomes and vesicles with tailored surface properties for membrane studies and controlled release.
• Pharmaceutical Intermediates: Acts as a sophisticated precursor in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Polymer Functionalization: Enables the introduction of cholesterol groups into polymers to enhance biocompatibility or self-assembly properties.
• Diagnostic Reagent Development: Utilized in creating cholesterol-tagged probes and sensors for biochemical assays.

Basic Information

Product Name	Cholest-5-En-3-Ol, 3-(6-(((2-Cyanoethoxy)(Diisopropylamino)Phosphino)Oxy)Hexyl)Carbamate
CAS No.	143723-64-2
Molecular Formula	C41H71N2O5P
Molecular Weight	703.00 g/mol
Synonyms	Cholesteryl-HEG Phosphoramidite; 6-((((2-Cyanoethoxy)(diisopropylamino)phosphino)oxy)hexyl) N-((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)carbamate; Cholesterol-TEG Phosphoramidite; 5-Cholesten-3β-ol 3-(6-(((2-cyanoethoxy)(diisopropylamino)phosphino)oxy)hexyl)carbamate; Phosphoramidite, cholesteryl-HEG; Cholesterol-based phosphoramidite linker; 3β-Cholesteryl Carbamate Phosphoramidite
EINECS	Contact for details

Quality Control

Our Cholest-5-En-3-Ol, 3-(6-(((2-Cyanoethoxy)(Diisopropylamino)Phosphino)Oxy)Hexyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.