Description

Emtricitabine CAS NO 143491-57-0 is a potent nucleoside reverse transcriptase inhibitor (NRTI) of significant pharmaceutical importance. This active pharmaceutical ingredient (API) is a cornerstone in modern antiretroviral therapy, valued for its high efficacy and favorable safety profile. It is primarily required by pharmaceutical manufacturers and research institutions for the formulation of combination therapies targeting HIV-1 and HBV infections.

Application

• Antiretroviral Drug Manufacturing: Primary API in fixed-dose combination (FDC) tablets for HIV-1 treatment.
• Hepatitis B Therapeutics: Key component in antiviral regimens for chronic Hepatitis B virus (HBV) infection.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for novel antiviral drug candidates and combination strategies.
• Generic Drug Production: Sourcing for the manufacture of bioequivalent generic versions of established combination therapies.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in laboratories.
• Formulation Development: Utilized in the development of various dosage forms, including oral tablets and potentially other novel delivery systems.

Basic Information

Product Name	Emtricitabine
CAS No.	143491-57-0
Molecular Formula	C8H10FN3O3S
Molecular Weight	247.24 g/mol
Synonyms	FTC; Coviracil; (-)-FTC; 5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; 2',3'-Dideoxy-5-fluoro-3'-thiacytidine; BW 524W91; Emtriva (Brand Name); 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
EINECS	Contact for details

Quality Control

Our Emtricitabine is manufactured under strict quality management systems. We provide material that meets or exceeds relevant pharmacopeial standards, including USP and EP monographs. Each batch undergoes comprehensive analytical testing, including assay, identification, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.