Description

2',3'-Dideoxy-5-Fluoro-3'-Thiacytidine is a fluorinated nucleoside analogue belonging to the class of cytidine derivatives. This compound is a key synthetic intermediate in the research and development of novel antiviral and anticancer therapeutics, particularly for targeting viral polymerases. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in medicinal chemistry and drug discovery programs. The high-purity material is essential for ensuring the reproducibility and efficacy of experimental results in preclinical studies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced nucleoside-based antiviral and anticancer drug candidates.
• Antiviral Research: Used in the study and development of novel therapeutics targeting viruses such as hepatitis B (HBV) and human immunodeficiency virus (HIV).
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic assays to study polymerase mechanisms and functions.
• Process Development: Used in scaling up synthetic routes for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2',3'-Dideoxy-5-Fluoro-3'-Thiacytidine
CAS No.	143491-54-7
Molecular Formula	C8H10FN3O2S
Molecular Weight	231.25 g/mol
Synonyms	5-Fluoro-3'-thia-2',3'-dideoxycytidine; 5-Fluoro-3TC; 5-Fluoro-Lamivudine; 5-F-ddC; 2',3'-Dideoxy-5-fluoro-3'-thiacytidine; β-L-2',3'-Dideoxy-5-fluoro-3'-thiacytidine; 5-Fluoro-(-)-2',3'-dideoxy-3'-thiacytidine; 5-Fluoro-BCH-189
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-5-Fluoro-3'-Thiacytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity reference standards and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.