Description

(Melle-4)Cyclosporin is a specialized, high-purity derivative of the well-known immunosuppressive agent Cyclosporin A. This compound matters for advanced pharmaceutical research and development, offering a critical tool for studying immune modulation and cellular signaling pathways with greater specificity. It is primarily needed by research institutions, pharmaceutical developers, and biotechnology companies engaged in the creation of novel therapeutics, particularly in the fields of immunology and oncology.

Application

• Pharmaceutical R&D: Serves as a key reference standard and intermediate in the development of next-generation immunosuppressive and immunomodulatory drugs.
• Biochemical Research: Used as a potent and selective probe to study calcineurin inhibition, T-cell activation, and intracellular signal transduction mechanisms.
• Metabolism Studies: Employed in pharmacokinetic and metabolic pathway investigations due to its modified structure compared to native cyclosporins.
• Process Development: Acts as a critical intermediate in the synthetic or semi-synthetic production routes for novel cyclosporin analogs.
• Quality Control: Utilized as an analytical reference standard for the identification and quantification of related substances in pharmaceutical quality assurance laboratories.

Basic Information

Product Name	(Melle-4)Cyclosporin
CAS No.	143205-42-9
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclosporin Melle-4; [Melle-4]-Cyclosporin A; Cyclosporin A, 4-(N-methylleucine)-; 4-(N-MeLeu)-Cyclosporin A; [Melle4]CsA; UNII-1V3G7B4T6N; (4-N-Methyl-L-leucine)-cyclosporin A
EINECS	Contact for details

Quality Control

Our (Melle-4)Cyclosporin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) documenting purity, related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.