Description

Lithocholic Acid 24-Ac-o-β-D-Glucuronide is a specific, conjugated bile acid derivative, a key metabolite formed during the enterohepatic circulation. This compound is of significant value as a high-purity reference standard and a critical intermediate in biochemical research and pharmaceutical development. It is primarily required by research institutions, diagnostic manufacturers, and pharmaceutical companies focused on hepatobiliary function, metabolic pathways, and the synthesis of novel therapeutic agents.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for the quantification and qualification of bile acid metabolites in biological samples via LC-MS/MS or HPLC.
• Diagnostic Kit Development: Serves as a critical calibrator or component in the development of in-vitro diagnostic (IVD) assays for liver function and metabolic disorders.
• Pharmaceutical Intermediate: Acts as a key synthetic building block or precursor in the research and development of novel therapeutic agents targeting nuclear receptors like FXR (Farnesoid X receptor).
• Metabolomics Studies: Essential for mapping and understanding complex metabolic pathways related to cholesterol metabolism and gut microbiome interactions.
• Toxicology & Pharmacokinetics: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to investigate the metabolism and elimination pathways of drug candidates.
• Academic Research: Used in university and institutional labs for fundamental studies on bile acid physiology, conjugation mechanisms, and their role in disease.

Basic Information

Product Name	Lithocholic Acid 24-Ac-o-β-D-Glucuronide
CAS No.	142780-61-8
Molecular Formula	C32H50O10
Molecular Weight	594.74 g/mol
Synonyms	24-Acetyl Lithocholic Acid Glucuronide; 3α-Hydroxy-5β-cholan-24-oic Acid 24-(Acetyl-β-D-glucopyranosiduronic Acid); Lithocholic Acid 24-Acetyl-β-D-Glucuronide; 24-Acetyl-β-D-glucopyranosiduronic acid, (3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl ester; Lithocholylglycine 24-Acetylglucuronide; LCA-24-Ac-GlcA
EINECS	Contact for details

Quality Control

Our Lithocholic Acid 24-Ac-o-β-D-Glucuronide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.