Description

(+)-Donepezil CAS NO 142698-19-9 is the pharmacologically active enantiomer of the acetylcholinesterase inhibitor donepezil. This high-purity chiral intermediate is critical for the synthesis of advanced pharmaceutical compounds targeting neurological conditions. It is an essential building block for pharmaceutical manufacturers and research institutions developing and producing enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key chiral intermediate in the commercial production of donepezil hydrochloride, the API for Alzheimer's disease medications.
• Neurological Research: Used in preclinical and clinical research to study the specific effects of the (+)-enantiomer on acetylcholinesterase inhibition and cognitive function.
• Process Development & Optimization: Serves as a reference standard and starting material for developing and scaling up enantioselective synthetic routes.
• Analytical Standard: Employed as a high-purity reference standard in HPLC, GC, and other analytical methods for quality control and regulatory submissions.
• Formulation Studies: Utilized in the development of novel drug delivery systems and formulations for improved therapeutic profiles.

Basic Information

Product Name	(+)-Donepezil
CAS No.	142698-19-9
Molecular Formula	C24H29NO3
Molecular Weight	379.49 g/mol
Synonyms	(+)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one; (R)-Donepezil; (+)-Donepezil Base; ARICEPT® Intermediate; E2020; (R)-(-)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one; (R)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
EINECS	Contact for details

Quality Control

Our (+)-Donepezil is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, to ensure it meets the stringent requirements for pharmaceutical intermediates. We provide Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, supporting compliance with cGMP and ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.