Description

Calanolide B is a naturally occurring, non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from the tropical tree *Calophyllum lanigerum*. This compound is of significant interest for its potent and specific antiviral activity, particularly against HIV-1. It is a critical intermediate and reference standard for pharmaceutical research and development in the antiviral and life sciences sectors.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel HIV-1 therapeutics.
• Antiviral Research: Used in biochemical and virological assays to study the mechanism of HIV-1 reverse transcriptase inhibition and drug resistance profiles.
• Medicinal Chemistry: Acts as a lead compound and scaffold for the synthesis of new analogs with improved pharmacokinetic properties.
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies on NNRTIs and antiviral drug discovery.
• Biotech Product Development: Utilized in the formulation and pre-clinical testing stages of new antiviral candidates.
• Quality Control: Functions as a high-purity analytical standard for the identification and quantification of Calanolide B in raw materials and finished products.

Basic Information

Product Name	Calanolide B
CAS No.	142632-33-5
Molecular Formula	C22H26O5
Molecular Weight	370.44 g/mol
Synonyms	(-)-Calanolide B; NSC 675451; Costatolide; (10R,11S,12S)-10,11-Dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-2H,6H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one; (+)-12-Hydroxycalanolide A
EINECS	Contact for details

Quality Control

Our Calanolide B is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.