Description

Calanolide A CAS NO 142632-32-4 is a naturally occurring, non-nucleoside coumarin derivative with significant biological activity. This compound is of paramount importance in pharmaceutical research and development due to its potent and specific anti-HIV-1 activity, functioning as a reverse transcriptase inhibitor. It is a critical target molecule for researchers in antiviral drug discovery, medicinal chemistry, and preclinical development programs focused on novel therapeutic agents.

Application

• Antiviral Research & Development: Primary application as a lead compound and reference standard in the discovery and development of novel anti-HIV-1 therapeutics.
• Medicinal Chemistry: Used as a core scaffold or intermediate for the synthesis of new chemical entities (NCEs) and analogs to study structure-activity relationships (SAR).
• Biochemical Assays: Serves as a positive control and pharmacological tool in enzymatic assays targeting HIV-1 reverse transcriptase.
• Pharmaceutical Reference Standard: Employed as a high-purity analytical standard for quality control, method development, and validation in pharmaceutical analysis.
• Preclinical Studies: Utilized in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicity profiles.
• Academic Research: Fundamental research in virology, pharmacology, and natural product chemistry to understand mechanisms of action and resistance.

Basic Information

Product Name	Calanolide A
CAS No.	142632-32-4
Molecular Formula	C22H26O5
Molecular Weight	370.44 g/mol
Synonyms	(+)-Calanolide A; NSC 675451; 11,12-Dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-4-propyl-; Costatolide; (+)-12-Hydroxycalanolide A (related); Anti-HIV agent (+)-Calanolide A
EINECS	Contact for details

Quality Control

Our Calanolide A is produced under strict quality management protocols to ensure the highest standards of purity and consistency required for research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR, MS), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.