Description

3-Chlorosulfonyl-2,6-Difluoro-Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its reactive sulfonyl chloride and carboxylic acid groups. This compound matters as a critical intermediate for synthesizing advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where its difluoro-substituted benzoic acid core imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in fine chemical, pharmaceutical, and crop protection industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in protease inhibitors and kinase-targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for sulfonamide-based compounds used in electronic display technologies.
• Polymer Modification: Functional monomer for introducing polar, reactive sites into specialty polymers and coatings.
• Dyestuff & Pigment Intermediate: Building block for synthesizing complex, high-performance dyes and pigments.
• Cross-coupling Reactions: The halogenated aromatic ring makes it a suitable substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A versatile reagent for academic and industrial research in medicinal and synthetic chemistry.

Basic Information

Product Name	3-Chlorosulfonyl-2,6-Difluoro-Benzoic Acid
CAS No.	142576-91-8
Molecular Formula	C7H3ClF2O4S
Molecular Weight	256.61 g/mol
Synonyms	2,6-Difluoro-3-(chlorosulfonyl)benzoic acid; Benzoic acid, 3-(chlorosulfonyl)-2,6-difluoro-; 3-(Chlorosulfonyl)-2,6-difluorobenzoic acid; 2,6-Difluorobenzoic acid-3-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Chlorosulfonyl-2,6-Difluoro-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry, inert conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.