Description

Fr 139317 CAS NO 142375-60-8 is a high-purity chemical compound used as a potent and selective endothelin A (ETA) receptor antagonist. This compound is a critical research tool for investigating the role of endothelin-1 in cardiovascular physiology and disease pathology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular, renal, and pulmonary research.

Application

• Pharmacological Research: A key reference standard and active agent in studies of endothelin receptor signaling pathways.
• Cardiovascular Disease Models: Used in preclinical research to investigate hypertension, atherosclerosis, and heart failure.
• Renal Function Studies: Applied in research exploring renal blood flow regulation, chronic kidney disease, and fibrosis.
• Pulmonary Hypertension Research: Employed in experimental models to study vasoconstriction and vascular remodeling in the lungs.
• Cell Signaling & Biochemistry: Serves as a selective inhibitor to elucidate ETA receptor-mediated cellular responses in vitro.
• Reference Standard: Used for analytical method development, validation, and quality control in related pharmaceutical development.

Basic Information

Product Name	Fr 139317
CAS No.	142375-60-8
Molecular Formula	C29H38N4O6
Molecular Weight	538.64 g/mol
Synonyms	FR139317; (R)-2-[(R)-2-[(S)-2-[[1-(Hexahydro-1H-azepinyl)]carbonyl]amino-4-methylpentanoyl]amino-3-[3-(1-methyl-1H-indolyl)]propionyl]amino-3-(2-pyridyl)propionic Acid; Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp); Endothelin A Receptor Antagonist I; BQ-123 analogue
EINECS	Contact for details

Quality Control

Our Fr 139317 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all test results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.