Description

Propanoic Acid, 2,2-Dimethyl-, [[[[2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methyl]Hydroxyphosphinyl]Oxy]Methyl Ester is a high-purity, chemically defined nucleotide prodrug intermediate. This compound is critical for enabling targeted delivery and enhanced bioavailability of active pharmaceutical ingredients in advanced therapeutic formulations. It is primarily utilized by pharmaceutical R&D and manufacturing organizations specializing in antiviral and anticancer nucleoside analog development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of prodrugs for antiviral medications, particularly nucleotide reverse transcriptase inhibitors (NRTIs).
• Antiviral Drug Development: Used in research and production of novel therapeutics targeting viruses such as HIV, Hepatitis B (HBV), and other viral pathogens.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic nucleoside analogs designed for improved cellular uptake and reduced side effects.
• Prodrug Synthesis: Enables the chemical modification of nucleoside monophosphates to create orally bioavailable and tissue-targeted prodrug forms.
• Biochemical Research: Employed in academic and industrial laboratories studying nucleotide metabolism, enzyme inhibition, and drug delivery mechanisms.
• GMP Manufacturing: Supplied as a qualified raw material for current Good Manufacturing Practice (cGMP) production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Propanoic Acid, 2,2-Dimethyl-, [[[[2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methyl]Hydroxyphosphinyl]Oxy]Methyl Ester
CAS No.	142341-05-7
Molecular Formula	C15H24N5O7P
Molecular Weight	417.36 g/mol
Synonyms	2,2-Dimethylpropionic Acid [[[[2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methyl]Hydroxyphosphinyl]Oxy]Methyl Ester; Pivaloyloxymethyl Adenine Monophosphate Prodrug; PMPA Prodrug Intermediate; (R)-9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Pivaloyloxymethyl Ester; GS-7340 Intermediate; Tenofovir Alafenamide (TAF) Related Compound; Adefovir Dipivoxil Analog; Nucleoside Phosphonate Prodrug Ester
EINECS	Contact for details

Quality Control

Our Propanoic Acid, 2,2-Dimethyl-, [[[[2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methyl]Hydroxyphosphinyl]Oxy]Methyl Ester is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and impurity profiles, suitable for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment. We support compliance with ICH Q7 guidelines and can supply material suitable for use in GMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.