Description

Adefovir Dipivoxil CAS NO 142340-99-6 is a diester prodrug of adefovir, a nucleotide analog reverse transcriptase inhibitor. This compound is a critical active pharmaceutical ingredient (API) used in the formulation of antiviral medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for chronic hepatitis B virus (HBV) infection.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of oral antiviral tablets.
• Pharmaceutical Research & Development for studying nucleotide analog efficacy and mechanisms.
• Reference Standard in analytical laboratories for quality control and method validation.
• Formulation Development for creating generic and novel drug delivery systems.
• Pre-clinical and Clinical Trial Material for investigative new drug (IND) applications.

Basic Information

Product Name	Adefovir Dipivoxil
CAS No.	142340-99-6
Molecular Formula	C20H32N5O8P
Molecular Weight	501.47 g/mol
Synonyms	9-[2-[[Bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine; Adefovir Dipivoxil; GS 0840; Hepsera (Brand Name); Bis(POM)-PMEA; Adefovir Bis(Pivaloyloxymethyl) Ester; PMEA Dipivoxil
EINECS	Contact for details

Quality Control

Our Adefovir Dipivoxil is manufactured and tested under a quality management system. We ensure the product meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.