Description

Entecavir is a potent and selective guanosine nucleoside analogue used as an antiviral agent. It is a critical active pharmaceutical ingredient (API) for the treatment of chronic hepatitis B virus (HBV) infection, offering high efficacy with a low genetic barrier to resistance. This compound is essential for pharmaceutical manufacturers developing antiviral medications. Its primary application is in the synthesis of finished dosage forms for global healthcare markets.

Application

• Primary Active Pharmaceutical Ingredient (API) in antiviral medications for chronic Hepatitis B.
• Key intermediate in advanced pharmaceutical research and development for nucleoside analogues.
• Reference standard in analytical laboratories for quality control and method validation.
• Biochemical research tool for studying viral polymerase inhibition mechanisms.
• Used in the formulation of oral tablets and other solid dosage forms.

Basic Information

Product Name	Entecavir
CAS No.	142217-69-4
Molecular Formula	C12H15N5O3
Molecular Weight	277.28 g/mol
Synonyms	BMS-200475; SQ-34676; 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one; Entecavir Monohydrate (common form); NSC 710305; (+)-Entecavir; Baraclude (Brand Name)
EINECS	Contact for details

Quality Control

Our Entecavir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) confirming identity, purity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.