Description

(-)-Donepezil CAS NO 142057-80-5 is the specific enantiomer of the acetylcholinesterase inhibitor donepezil, known for its high pharmacological activity. This compound is a critical chiral building block and reference standard in the research and development of treatments for neurodegenerative disorders. It is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on neurology, cognitive enhancement, and chiral chemistry.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral precursor in the synthesis of donepezil hydrochloride, the active component in medications for Alzheimer's disease.
• Pharmaceutical Reference Standard: Used for quality control, method validation, and calibration in HPLC and other analytical assays within pharmaceutical manufacturing.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate acetylcholinesterase inhibition mechanisms and cognitive function.
• Chiral Synthesis: Serves as a high-purity starting material or intermediate for the synthesis of novel chiral compounds targeting the central nervous system.
• Analytical Testing: Utilized as a certified reference material (CRM) in forensic, clinical, and regulatory testing laboratories.

Basic Information

Product Name	(-)-Donepezil
CAS No.	142057-80-5
Molecular Formula	C24H29NO3
Molecular Weight	379.49 g/mol
Synonyms	(-)-Donepezil; (R)-Donepezil; (R)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; Aricept Impurity; Donepezil Related Compound A; E2020; (R)-E2020; (R)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
EINECS	Contact for details

Quality Control

Our (-)-Donepezil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.