Description

Donepezilhcl CAS NO 142057-77-0 is the hydrochloride salt of Donepezil, a potent and selective acetylcholinesterase inhibitor. This active pharmaceutical ingredient (API) is critical for the formulation of treatments targeting cognitive decline. It is primarily required by pharmaceutical manufacturers and research institutions engaged in developing and producing medications for neurological conditions. Our supply ensures high purity and consistent quality for reliable downstream processing.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of prescription medications for Alzheimer's disease and other dementias.
• Neurological Research: A key compound in preclinical and clinical studies investigating cholinergic pathways and cognitive function.
• Generic Drug Formulation: Sourcing for the production of generic versions of acetylcholinesterase inhibitor drugs following patent expiry.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Dosage Form Development: Used in R&D for developing various oral solid dosage forms such as tablets and capsules.

Basic Information

Product Name	Donepezilhcl
CAS No.	142057-77-0
Molecular Formula	C24H29NO3•HCl
Molecular Weight	415.95 g/mol
Synonyms	Donepezil Hydrochloride; E2020; Aricept (Brand Name); (±)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one Hydrochloride; 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine Hydrochloride; (RS)-Donepezil Hydrochloride; 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxyindan-1-one Hydrochloride
EINECS	Contact for details

Quality Control

Our Donepezilhcl is manufactured under strict quality management systems. It undergoes rigorous analytical testing to meet high-purity standards suitable for pharmaceutical applications, including HPLC assay, related substance profiling, and residual solvent analysis. Certificates of Analysis (COA) documenting compliance with in-house specifications are available for every batch. We support compliance with ICH Q7 guidelines and relevant pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Ensure the storage area is well-ventilated and separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.