Description

N2-(Deoxyguanosin-8-Yl)-2-Amino-3,8-Dimethylimidazo[4,5-F]Quinoxaline is a specific DNA adduct formed from the reaction of a heterocyclic aromatic amine (HAA) with deoxyguanosine. This compound matters as a critical biomarker for studying exposure to dietary and environmental mutagens, providing direct evidence of DNA damage. Researchers in toxicology, molecular epidemiology, and cancer research need this high-purity reference standard to investigate mechanisms of carcinogenesis, assess genotoxic risk, and validate analytical methods.

Application

• Biomarker Research: Used as a definitive reference standard in mass spectrometry (LC-MS/MS) for the quantification of specific DNA adducts in biological samples.
• Toxicology Studies: Essential for investigating the metabolic activation, DNA binding, and repair mechanisms of heterocyclic aromatic amines (HAAs) like MeIQx.
• Molecular Epidemiology: Enables correlation studies between dietary exposure (e.g., from cooked meats) and DNA adduct levels in human tissues.
• Method Development & Validation: Serves as a critical calibrant and quality control material for developing highly sensitive analytical assays in forensic and diagnostic laboratories.
• Cancer Research: Facilitates studies on the role of specific DNA lesions in mutagenesis and the initiation of chemical carcinogenesis.
• Standards for Regulatory Testing: Supports compliance and safety testing for food and chemical industries by providing a traceable standard for genotoxicity assessment.

Basic Information

Product Name	N2-(Deoxyguanosin-8-Yl)-2-Amino-3,8-Dimethylimidazo[4,5-F]Quinoxaline
CAS No.	142038-31-1
Molecular Formula	C22H24N10O4
Molecular Weight	492.49 g/mol
Synonyms	N2-(Deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; 8-(Deoxyguanosin-N2-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; dG-C8-MeIQx; MeIQx-deoxyguanosine adduct; 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline-deoxyguanosine adduct; DNA adduct of MeIQx; N-(Deoxyguanosin-8-yl)-MeIQx
EINECS	Contact for details

Quality Control

Our N2-(Deoxyguanosin-8-Yl)-2-Amino-3,8-Dimethylimidazo[4,5-F]Quinoxaline is produced under strict quality management protocols to ensure the highest standard of purity and batch-to-batch consistency required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.