Description

n-(2-Amino-3,8-Dimethylimidazo[4,5-F]Quinoxalin-5-Yl) 2'-Deoxyguanosine is a high-purity, heterocyclic amine-modified nucleoside derivative of significant interest in biochemical and pharmaceutical research. This compound is valued for its role as a key intermediate and reference standard in the study of DNA adducts and mutagenesis. It is primarily sought by research institutions, diagnostic developers, and pharmaceutical companies engaged in toxicology, biomarker discovery, and the development of analytical methods for detecting DNA damage.

Application

• Biochemical Research Standard: Serves as a critical reference material for quantifying DNA adducts formed by heterocyclic aromatic amines (HAAs) in experimental models.
• Toxicology & Carcinogenesis Studies: Used to investigate the metabolic activation, DNA binding, and mutagenic potential of specific dietary and environmental compounds.
• Analytical Method Development: Essential for calibrating and validating sensitive detection techniques such as HPLC-MS/MS, 32P-postlabeling, and immunoassays in biological matrices.
• Biomarker Discovery: Employed in studies aiming to identify and validate exposure biomarkers for epidemiological and risk assessment research.
• Pharmaceutical Impurity Profiling: Acts as a known impurity or degradation product standard in the quality control of related pharmaceutical compounds.
• Synthetic Chemistry Intermediate: Used in the synthesis of more complex molecules for probing DNA repair mechanisms or developing diagnostic probes.

Basic Information

Item	Details
Product Name	n-(2-Amino-3,8-Dimethylimidazo[4,5-F]Quinoxalin-5-Yl) 2'-Deoxyguanosine
CAS No.	142038-30-0
Molecular Formula	C19H21N9O4
Molecular Weight	439.43 g/mol
Synonyms	N2-(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxalin-5-yl)-2'-deoxyguanosine; 5-(2'-Deoxyguanosin-N2-yl)-3,8-dimethylimidazo[4,5-f]quinoxalin-2-amine; dG-C8-MelQx; 2'-Deoxyguanosine-C8-MelQx adduct; MelQx-dG adduct; IQ-like compound adduct; DNA adduct of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline
EINECS	Contact for details

Quality Control

Every batch of n-(2-Amino-3,8-Dimethylimidazo[4,5-F]Quinoxalin-5-Yl) 2'-Deoxyguanosine is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing comprehensive analytical results, including purity by HPLC, structural confirmation, and impurity profiles, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under low-light conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.