Description

Saredutant is a potent and selective non-peptide antagonist of the neurokinin 2 (NK2) receptor. This compound is a critical research tool and pharmaceutical intermediate for investigating the role of tachykinins in various physiological and pathological processes. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract research organizations (CROs) focused on developing novel therapeutics for conditions related to the central nervous system and smooth muscle function.

Application

• Pharmacological Research: A key reference standard for studying the function and modulation of the NK2 receptor in vitro and in vivo.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the synthesis of new neurokinin receptor antagonists targeting conditions like anxiety, depression, and urinary incontinence.
• Biochemical Assay Development: Used to validate and calibrate high-throughput screening (HTS) assays for identifying new NK2 receptor modulators.
• Neuroscience Studies: Employed to elucidate the role of substance P and related peptides in pain transmission, inflammation, and smooth muscle contraction.
• Academic & Clinical Research: Essential for preclinical studies investigating the therapeutic potential of NK2 receptor blockade.

Basic Information

Product Name	Saredutant
CAS No.	142001-63-6
Molecular Formula	C₂₀H₂₃N₃O₃S
Molecular Weight	385.48 g/mol
Synonyms	SR 48968; Saredutant Hydrochloride; (S)-N-Methyl-N[4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl]benzamide; SR-48968; SR48968; NK2 Receptor Antagonist SR48968
EINECS	Contact for details

Quality Control

Our Saredutant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.