Description

Rapamycin, 32-o-Demethyl- is a key chemical derivative of the potent immunosuppressant and mTOR inhibitor, rapamycin. This compound is of significant interest for its role as a crucial intermediate in the synthesis of novel rapamycin analogs and for research into structure-activity relationships. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on developing next-generation therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel rapamycin (sirolimus) analogs and derivatives with modified biological activity.
• Biochemical Research: Used as a reference standard and tool compound in studies investigating the mTOR signaling pathway and its role in cell growth, proliferation, and autophagy.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies aimed at developing new immunosuppressants or anti-cancer agents.
• API Development: Employed in the research and development stages of new Active Pharmaceutical Ingredients (APIs) targeting mTOR inhibition.
• Life Science Reagent: Supplied to research laboratories for use in cell-based assays and molecular biology experiments.

Basic Information

Product Name	Rapamycin, 32-o-Demethyl-
CAS No.	141392-23-6
Molecular Formula	C50H77NO13
Molecular Weight	900.15 g/mol
Synonyms	32-O-Demethylrapamycin; 32-O-Desmethylrapamycin; 32-Demethoxyrapamycin; 32-Demethoxysirolimus; 32-O-Demethylsirolimus; Demethylrapamycin; AY 22989
EINECS	Contact for details

Quality Control

Our Rapamycin, 32-o-Demethyl- is produced under a rigorous quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.