Description

1,25-Dihydroxy-21-Norvitamin D3 is a synthetic analog of the active form of vitamin D, calcitriol, characterized by the absence of the exocyclic methylene group at the C-21 position. This structural modification is significant for research into the structure-activity relationships of vitamin D receptor (VDR) ligands and their biological effects. It is a critical compound for pharmaceutical R&D, particularly in the study of calcium metabolism, cell differentiation, and immune modulation. This high-purity intermediate is essential for researchers and manufacturers developing novel therapeutics and biochemical tools.

Application

• Pharmaceutical Research & Development: A key reference standard and synthetic intermediate for developing novel vitamin D analogs and metabolites.
• Biochemical Research: Used in studies investigating the vitamin D endocrine system, VDR binding affinity, and gene regulation.
• Metabolic Studies: Employed as a tool compound to explore calcium and phosphate homeostasis in preclinical models.
• Cell Biology & Differentiation: Applied in *in vitro* studies to examine the effects on cell proliferation, differentiation, and apoptosis.
• Reference Material: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Academic Research: Utilized in universities and research institutes for fundamental studies in endocrinology and molecular biology.

Basic Information

Product Name	1,25-Dihydroxy-21-Norvitamin D3
CAS No.	141300-55-2
Molecular Formula	C₂₆H₄₂O₃
Molecular Weight	402.61 g/mol
Synonyms	21-Nor-1,25-dihydroxyvitamin D3; 21-Norcalcitriol; 1α,25-Dihydroxy-21-norcholecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol; 21-Nor-1α,25-dihydroxyvitamin D₃; 21-Nor-1,25-(OH)₂D₃
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-21-Norvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.