Description

Abacavir CAS NO 141271-12-7 is a potent nucleoside reverse transcriptase inhibitor (NRTI) used as an active pharmaceutical ingredient (API). This compound is critical for the formulation of antiretroviral medications, playing a vital role in the global fight against HIV/AIDS. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of combination therapies for HIV-1 infection.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiretroviral drug formulations for the treatment of HIV-1 infection.
• Fixed-Dose Combination Drugs: Used in combination with other antiretroviral agents (e.g., lamivudine, zidovudine) in single-tablet regimens.
• Clinical Research: Serves as a reference standard and key material in virology and pharmacology research studies.
• Generic Drug Manufacturing: Essential for the production of bioequivalent generic versions of branded antiretroviral medications.
• Pre-Exposure Prophylaxis (PrEP): Investigational component in research for preventative HIV treatment strategies.
• Pediatric Formulations: Used in the development of appropriate dosage forms for pediatric HIV treatment.

Basic Information

Product Name	Abacavir
CAS No.	141271-12-7
Molecular Formula	C14H18N6O
Molecular Weight	286.33 g/mol
Synonyms	Abacavir Sulfate; Ziagen; ABC; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; 1592U89; Cyclopropavir; Abacavirum; ATC Code J05AF06
EINECS	Contact for details

Quality Control

Our Abacavir is manufactured under strict quality management systems. We provide material that meets or exceeds the requirements of major pharmacopoeias, including USP and EP monographs. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure compliance with ICH guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities NMT 1.0% Any individual impurity NMT 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.