Description

15-o-Desmethylascomycin is a potent and selective macrolide lactone derivative, structurally related to tacrolimus (FK506) and ascomycin. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of immunosuppressive pathways and novel therapeutic agents. It is primarily utilized by researchers and manufacturers in the biotechnology and pharmaceutical industries for drug discovery, target validation, and as a key reference standard.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel immunosuppressive and anti-inflammatory drug candidates.
• Biochemical Research: Used as a potent and selective inhibitor in cellular signaling pathway studies, particularly those involving calcineurin.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Drug Discovery: Employed in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic entities.
• Mechanistic Studies: A vital tool for investigating the molecular mechanisms of immunophilin ligands and their biological targets.

Basic Information

Product Name	15-o-Desmethylascomycin
CAS No.	141170-83-4
Molecular Formula	C42H65NO12
Molecular Weight	775.97 g/mol
Synonyms	15-O-Desmethylascomycin; 15-Desmethoxyascomycin; 15-Demethoxyascomycin; 15-O-Demethylascomycin; 15-Desmethoxy FK-520; 15-O-Desmethyl FK-520; 15-Demethoxy FK-520; Ascomycin, 15-O-desmethyl-
EINECS	Contact for details

Quality Control

Our 15-o-Desmethylascomycin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.