Description

The (S,S)-Duthaler-Hafner Reagent is a specialized chiral organometallic reagent, CAS NO 140462-73-3, designed for highly stereoselective transformations in advanced organic synthesis. Its primary value lies in enabling the efficient and predictable construction of complex molecules with defined stereochemistry, a critical requirement in modern pharmaceutical and agrochemical development. This reagent is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-purity building blocks for asymmetric synthesis.

Application

• Asymmetric Synthesis: A key reagent for the stereocontrolled formation of carbon-carbon and carbon-heteroatom bonds in complex molecule assembly.
• Pharmaceutical Intermediates: Used in the synthesis of chiral active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and infectious diseases.
• Agrochemical Development: Employed in creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Natural Product Synthesis: Facilitates the total synthesis of complex natural products with multiple stereocenters.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral catalysts and auxiliaries used in homogeneous catalysis.
• Material Science Research: Applied in the development of chiral polymers and advanced organic materials with specific optical properties.

Basic Information

Product Name	(S,S)-Duthaler-Hafner Reagent
CAS No.	140462-73-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(S,S)-Duthaler-Hafner Titanium Reagent; (S,S)-Duthaler-Hafner Titanacycle; (S,S)-1,2-Bis(tert-butylsulfinyl)ethane Titanium Complex; Hafner-Duthaler Reagent; Chiral Titanium Ethylene Glycolate; Asymmetric Titanium Reagent; Stereoselective Titanium Complex; (S,S)-BISTI-Ti Reagent
EINECS	Contact for details

Quality Control

Our (S,S)-Duthaler-Hafner Reagent is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance. Each lot undergoes rigorous analytical testing, including chiral purity assessment by HPLC and spectroscopic identification, to meet the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chiral excess is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen). Due to its hygroscopic (moisture-sensitive) nature, the reagent must be handled in a moisture-free environment, such as a glovebox or under a continuous inert gas purge, to maintain stability and reactivity.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid or solution
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Assay (Titration)	Contact for details
Solvent Content (GC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.