Description

tert-Butyl 4-Amino-2-Fluorobenzoate is a high-purity fluorinated benzoate derivative, serving as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis. Its value lies in the strategic combination of the tert-butyl ester protecting group and the ortho-fluorine substituent, which are essential for modulating the reactivity, stability, and pharmacokinetic properties of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for advanced polymers and liquid crystals, contributing to materials with specific optical or electronic properties.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & R&D: Utilized in medicinal chemistry and synthetic organic chemistry research for exploring new reaction pathways and creating compound libraries.

Basic Information

Item	Details
Product Name	tert-Butyl 4-Amino-2-Fluorobenzoate
CAS No.	140373-77-9
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	4-Amino-2-fluorobenzoic acid tert-butyl ester; 2-Fluoro-4-aminobenzoic acid tert-butyl ester; tert-Butyl 2-fluoro-4-aminobenzoate; 4-Amino-2-fluorobenzoic acid 1,1-dimethylethyl ester; Benzoic acid, 4-amino-2-fluoro-, 1,1-dimethylethyl ester; 140373-77-9; tert-Butyl 4-amino-2-fluorobenzoate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-2-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.