Description

D-[5-13C]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, where the carbon-5 position is enriched with the 13C isotope. This precise labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing critical insights into biochemical pathways. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic companies engaged in tracer studies, NMR spectroscopy, and mass spectrometry-based quantification.

Application

• Metabolic Flux Analysis (MFA): As a 13C-labeled tracer to map and quantify carbon flow through central metabolic pathways like the pentose phosphate pathway.
• NMR Spectroscopy: Serving as a standard or internal reference for structural elucidation and dynamic studies of nucleic acids and nucleotide cofactors.
• Mass Spectrometry (MS): Used as an internal standard for the accurate quantification of ribose and its metabolites in complex biological samples via LC-MS or GC-MS.
• Pharmaceutical Research: Investigating the biosynthesis and mechanism of action of nucleoside-based drugs and antiviral agents.
• Diagnostic Assay Development: Employed in the calibration and validation of clinical assays measuring ribose-related metabolic disorders.
• Biochemical Research: Studying enzyme kinetics, carbohydrate metabolism, and the role of ribose in energy production (e.g., ATP synthesis).

Basic Information

Product Name	D-[5-13C]Ribose
CAS No.	139657-62-8
Molecular Formula	C413CH10O5
Molecular Weight	151.12 g/mol (for 13C5 labeled)
Synonyms	D-Ribose-5-13C; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-5-13C; 5-13C-D-Ribose; Ribose (D-5-13C); Stable Isotope Labeled D-Ribose; 13C5-Ribose (position-specific); D-(-)-Ribose-5-13C
EINECS	Contact for details

Quality Control

Every batch of D-[5-13C]Ribose is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment, and specific optical rotation. A detailed Certificate of Analysis (COA), providing batch-specific data from advanced analytical techniques (NMR, HPLC, MS), is supplied with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Specific Optical Rotation	-20.0° to -23.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.