Description

Thioformyldistamycin is a synthetic derivative of the natural antibiotic distamycin A, incorporating a thioformyl group that modifies its biological activity and binding properties. This compound is of significant interest in pharmaceutical research and development due to its potential as a DNA minor groove binder, offering a platform for designing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of anticancer and antiviral drugs, as well as in biochemical studies targeting specific genetic sequences.

Application

• Pharmaceutical R&D: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel anticancer therapies.
• Antiviral Agent Research: Investigated for its potential to inhibit viral replication by binding to viral DNA.
• Biochemical Tool: Used in molecular biology and genetics research as a sequence-specific DNA binding agent for studying gene regulation and function.
• Medicinal Chemistry: Acts as a lead compound for the synthesis of analogs with enhanced potency, selectivity, and pharmacokinetic profiles.
• Academic Research: Employed in university and institutional labs for fundamental studies on DNA-ligand interactions and drug design principles.

Basic Information

Product Name	Thioformyldistamycin
CAS No.	139341-61-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thioformyl-distamycin A; Distamycin A thioformyl derivative; NSC 652287; 1-Methyl-4-[[1-methyl-4-[[1-methyl-4-[(thioformylamino)methyl]-1H-pyrrole-2-carbonyl]amino]-1H-pyrrole-2-carbonyl]amino]-1H-pyrrole-2-carboxamide; FCE 24517; PNU-151807
EINECS	Contact for details

Quality Control

Our Thioformyldistamycin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced analytical techniques such as HPLC and NMR. We adhere to cGMP guidelines where applicable to support our clients' preclinical and development phase requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under conditions that minimize exposure to light and atmospheric moisture to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.