Description

n-Acetoxy Cyclosporin A Acetate is a chemically modified derivative of the potent immunosuppressive agent Cyclosporin A. This compound is of significant interest in pharmaceutical research and development for its potential to alter the pharmacokinetic and pharmacodynamic profile of the parent molecule. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, prodrug development, and advanced metabolic studies.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel Cyclosporin A analogs with potentially improved efficacy or reduced side effects.
• Prodrug Development: Serves as a precursor in the design of prodrug formulations aimed at enhancing bioavailability or targeted drug delivery.
• Metabolic & Pharmacokinetic Research: Used in studies to investigate the metabolic pathways and stability of cyclosporine derivatives.
• Bioconjugation & Labeling: The acetoxy group provides a handle for further chemical modifications, conjugation with other molecules, or isotopic labeling.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Immunology Research: Used in preclinical research to study structure-activity relationships (SAR) of immunosuppressive compounds.

Basic Information

Product Name	n-Acetoxy Cyclosporin A Acetate
CAS No.	138957-23-0
Molecular Formula	C65H113N11O14
Molecular Weight	1264.66 g/mol
Synonyms	Cyclosporin A, 3-O-Acetyl-; 3-Acetylcyclosporin A; Cyclosporin A Acetate; [Acetyl-3]-Cyclosporin A; 3-O-Acetylcyclosporin A; n-Acetoxy Cyclosporin A; Cyclosporine A Acetate; CsA Acetate
EINECS	Contact for details

Quality Control

Our n-Acetoxy Cyclosporin A Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.