Description

3-Fluoro-α-Methyl-4-(4-Isopropyl-2-Thiazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research interest. Its core value lies in its role as a key synthetic precursor for the development of novel COX-2 inhibitors and other therapeutic agents targeting inflammation and pain. This compound is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of COX-2 selective inhibitors and other non-steroidal anti-inflammatory drugs (NSAIDs).
• Active Pharmaceutical Ingredient (API) Development: Critical precursor in research and process development for new analgesic and anti-inflammatory compounds.
• Biochemical Research: Used as a reference standard and probe in studies investigating cyclooxygenase enzyme pathways and mechanisms of action.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of target drug substances.
• Academic Research: Utilized in university and institutional laboratories for medicinal chemistry projects and novel drug discovery.

Basic Information

Product Name	3-Fluoro-α-Methyl-4-(4-Isopropyl-2-Thiazolyl)Benzeneacetic Acid
CAS No.	138568-72-6
Molecular Formula	C16H18FNO2S
Molecular Weight	307.38 g/mol
Synonyms	2-(3-Fluoro-4-[(4-isopropyl-1,3-thiazol-2-yl)]phenyl)propanoic acid; α-Methyl-3-fluoro-4-(4-isopropyl-2-thiazolyl)benzeneacetic acid; 3-Fluoro-α-methyl-4-(4-(1-methylethyl)-2-thiazolyl)benzenacetic acid; Valdecoxib intermediate; COX-2 inhibitor intermediate; SC-65872 intermediate; Parecoxib sodium intermediate precursor; Benzeneacetic acid, 3-fluoro-α-methyl-4-(4-(1-methylethyl)-2-thiazolyl)-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-α-Methyl-4-(4-Isopropyl-2-Thiazolyl)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.