Description

(-)-Trimipramine Maleate CAS NO 138283-60-0 is the maleate salt of the (-)-enantiomer of trimipramine, a tricyclic antidepressant (TCA) compound. This specific enantiomeric form is of significant interest in pharmaceutical research and development for its potential role in studying stereoselective pharmacological activity. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for manufacturers and research institutions focused on neuropharmacology and chiral drug synthesis.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure antidepressant drugs.
• Biochemical Research: Employed in preclinical studies to investigate the stereospecific mechanisms of action, metabolism, and receptor binding of tricyclic antidepressants.
• Pharmacopoeial Testing: Utilized as a certified reference material (CRM) for compliance with pharmacopoeial monographs (e.g., USP, EP).
• Academic Research: A vital compound for universities and institutions conducting studies in medicinal chemistry, psychiatry, and neurobiology.
• Method Development: Critical for developing and calibrating advanced analytical techniques like chiral HPLC and LC-MS.

Basic Information

Product Name	(-)-Trimipramine Maleate
CAS No.	138283-60-0
Molecular Formula	C23H29N3O4
Molecular Weight	411.50 g/mol
Synonyms	(-)-Trimipramine maleate salt; (3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-2-methylpropyl)dimethylamine (2Z)-2-butenedioate; Levotrimipramine maleate; (S)-Trimipramine maleate; ST-1389; ST 1389; Surmontil (related to racemic form); Maleic acid trimipramine salt
EINECS	Contact for details

Quality Control

Our (-)-Trimipramine Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and enantiomeric excess. We provide full traceability and support our products with a detailed Certificate of Analysis (COA), which includes data from HPLC, chiral analysis, and other relevant pharmacopoeial tests. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.