Description

Doxepin CAS NO 1668-19-5 is a tricyclic antidepressant compound of significant pharmaceutical importance. Its primary value lies in its potent histamine H1 and H2 receptor antagonism, making it a key active pharmaceutical ingredient (API) for the treatment of depression, anxiety disorders, and pruritus. This compound is essential for manufacturers in the global pharmaceutical industry engaged in the production of generic and branded medications. Rigorous quality control ensures its suitability for high-value therapeutic applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in antidepressant and anti-anxiety medications.
• Topical Formulations: Used in creams and lotions for the treatment of severe itching (pruritus), such as that caused by eczema or dermatitis.
• Neuropharmacology Research: Serves as a standard or investigational compound in studies related to neurotransmitter reuptake inhibition.
• Generic Drug Manufacturing: Critical for producing cost-effective generic versions of doxepin-based therapeutics for global markets.
• Reference Standard: Utilized in analytical laboratories as a high-purity standard for quality control and method validation.
• Dermatological Preparations: Incorporated into specialized formulations for managing chronic skin conditions.

Basic Information

Product Name	Doxepin
CAS No.	1668-19-5
Molecular Formula	C19H21NO
Molecular Weight	279.38 g/mol
Synonyms	Doxepin Hydrochloride (salt form); Sinequan; Adapin; 3-Dibenz[b,e]oxepin-11(6H)ylidene-N,N-dimethyl-1-propanamine; NSC-108160; P-3693A; Quitaxon; Aponal
EINECS	Contact for details

Quality Control

Our Doxepin is manufactured under strict quality management systems to ensure it meets the stringent requirements of the pharmaceutical industry. Each batch is tested against relevant pharmacopeial standards (such as USP/EP) for identity, purity, and potency. A comprehensive Certificate of Analysis (COA), detailing results for assay, related substances, residual solvents, and other critical parameters, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.