Description

D-Glucose-1,2-13C2 is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the C1 and C2 positions. This precise labeling makes it an indispensable tool for advanced metabolic research and diagnostic applications, enabling accurate tracing of glucose utilization and metabolic flux. It is primarily utilized by research institutions, pharmaceutical developers, and clinical diagnostic laboratories engaged in tracer studies, NMR spectroscopy, and mass spectrometry.

Application

• Metabolic Pathway Analysis: Used as a tracer to study glycolysis, gluconeogenesis, and the pentose phosphate pathway in cell cultures, tissues, and whole organisms.
• Quantitative NMR (qNMR): Serves as a high-purity internal standard for the quantitative determination of metabolites and the purity assessment of pharmaceutical compounds.
• Mass Spectrometry (MS) Standards: Employed as an internal standard in LC-MS and GC-MS workflows for the absolute quantification of glucose and related metabolites in complex biological samples.
• Clinical Research: Facilitates in-depth studies of metabolic disorders such as diabetes, insulin resistance, and cancer metabolism.
• Drug Metabolism & Pharmacokinetics (DMPK): Tracks the metabolic fate of new drug candidates that interact with glucose metabolic pathways.
• Stable Isotope-Labeled Reference Material: Used in the production and calibration of diagnostic assays and kits.

Basic Information

Product Name	D-Glucose-1,2-13C2
CAS No.	138079-87-5
Molecular Formula	C132H12O6
Molecular Weight	182.14 g/mol (for 13C2 isotopologue)
Synonyms	1,2-13C2-D-Glucose; [1,2-13C2]Glucose; D-(+)-Glucose-1,2-13C2; Glucose-1,2-13C2; 13C Labeled D-Glucose; (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal-1,2-13C2; Stable Isotope-Labeled Glucose; Deuterated Glucose (common misnomer)
EINECS	Contact for details

Quality Control

Our D-Glucose-1,2-13C2 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C at the labeled positions), chemical purity (by HPLC), and identity confirmation (by NMR and IR). We adhere to relevant standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (13C at C1 & C2)	≥99 atom %
Water Content (KF)	≤1.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.