Description

(S)-N,n-Dimethyl-1-((R)-2-Diphenylphosphino)Ferrocenylethylamine CAS NO 137695-36-4 is a highly specialized chiral ferrocenylphosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its unique three-dimensional structure, which provides exceptional stereocontrol in transition metal-catalyzed reactions, enabling the synthesis of enantiomerically pure compounds. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance, reliable ligands for creating novel chiral molecules.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral intermediates in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) and allylic substitution reactions to construct complex chiral carbon frameworks.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Development: Used in the synthesis of chiral herbicides, fungicides, and pesticides, where the correct stereochemistry is vital for efficacy and environmental safety.
• Fine Chemical and Fragrance Manufacturing: Enables the asymmetric synthesis of complex flavor and fragrance compounds with high optical purity.
• Academic and Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research within university and corporate laboratories.
• Catalyst Screening Libraries: A key component in high-throughput screening kits for discovering new catalytic transformations.

Basic Information

Item	Details
Product Name	(S)-N,n-Dimethyl-1-((R)-2-Diphenylphosphino)Ferrocenylethylamine
CAS No.	137695-36-4
Molecular Formula	C26H28FeNP
Molecular Weight	441.33 g/mol
Synonyms	(R)-(S)-Josiphos; (R)-(S)-PPF-PCy2; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldimethylamine; Josiphos SL-J009-1; SL-J009-1; (S)-N,N-Dimethyl-1-((R)-2-(diphenylphosphino)ferrocenyl)ethylamine; (1R)-1-[(1S)-2-(Diphenylphosphino-kP)ferrocen-1-yl]-N,N-dimethylethanamine
EINECS	Contact for details

Quality Control

Every batch of our (S)-N,n-Dimethyl-1-((R)-2-Diphenylphosphino)Ferrocenylethylamine undergoes rigorous analytical testing to ensure high chemical purity and enantiomeric excess (ee), which are critical for catalytic performance. Our quality assurance protocols are designed to meet the stringent requirements of process chemistry and GMP environments. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/NMR), chiral purity, and physical properties is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.