Description

(-)-2,3-o-Isopropylidene-1,1,4,4-Tetra(2-Naphthyl)-L-Threitol is a high-value, chiral organic compound primarily utilized as a sophisticated ligand or catalyst precursor in asymmetric synthesis. Its core value proposition lies in its ability to impart high enantioselectivity in critical chemical transformations, enabling the production of single-enantiomer intermediates essential for advanced pharmaceuticals and fine chemicals. This product is specifically needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric catalysis, particularly for additions to carbonyl compounds.
• As a key building block for the synthesis of complex, enantiomerically pure natural products and pharmaceutical intermediates.
• In the development and scale-up of stereoselective hydrogenation and transfer hydrogenation reactions.
• For research into novel catalytic systems for C-C and C-X bond formation with high optical purity.
• As a resolving agent or chiral auxiliary in the separation or synthesis of enantiomers.
• In academic and industrial R&D focused on organocatalysis and metal-organic catalysis.

Basic Information

Item	Details
Product Name	(-)-2,3-o-Isopropylidene-1,1,4,4-Tetra(2-Naphthyl)-L-Threitol
CAS No.	137365-09-4
Molecular Formula	C46H40O4
Molecular Weight	656.81 g/mol
Synonyms	(-)-1,1,4,4-Tetra(2-naphthyl)-2,3-O-isopropylidene-L-threitol; (2R,3R)-1,1,4,4-Tetrakis(2-naphthyl)-2,3-O-isopropylidene-1,1,4,4-tetrahydroxybutane; TADDOL Derivative; L-Threitol, 1,1,4,4-tetra-2-naphthalenyl-2,3-O-(1-methylethylidene)-, (2R,3R)-; Chiral TADDOL-type ligand; Asymmetric synthesis ligand 137365-09-4.
EINECS	Contact for details

Quality Control

Our (-)-2,3-o-Isopropylidene-1,1,4,4-Tetra(2-Naphthyl)-L-Threitol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR spectroscopy, to ensure high chemical and optical purity consistent with research and process chemistry requirements. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.