Description

1-(2',3',5',6'-Tetradeoxy-3'-Fluoro-6'-Phosphono-Erythro-Hexofuranosyl)Thymine is a sophisticated fluorinated nucleoside phosphonate analog, representing a key building block in advanced pharmaceutical research and development. Its primary value lies in its role as a potent antiviral and anticancer prodrug precursor, designed for targeted therapeutic action with enhanced metabolic stability. This high-purity intermediate is critically needed by research institutions and pharmaceutical companies engaged in the synthesis of next-generation nucleotide-based therapeutics, particularly for targeting viral polymerases and specific oncogenic pathways.

Application

• Antiviral Drug Development: Serves as a critical synthetic intermediate for prodrugs targeting viruses such as Hepatitis B (HBV), Hepatitis C (HCV), and other DNA viruses.
• Oncology Research: Used in the synthesis of nucleotide analogs designed to inhibit cancer cell proliferation by interfering with DNA synthesis and repair mechanisms.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to understand polymerase function and nucleotide metabolism.
• Prodrug Synthesis: A key precursor for creating orally bioavailable prodrug forms of active nucleotide metabolites, improving drug delivery and pharmacokinetics.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and safety profiles of new chemical entities.
• Reference Standard: Supplied as a high-purity compound for use as an analytical standard in quality control and regulatory submissions for novel therapeutics.

Basic Information

Item	Details
Product Name	1-(2',3',5',6'-Tetradeoxy-3'-Fluoro-6'-Phosphono-Erythro-Hexofuranosyl)Thymine
CAS No.	137248-58-9
Molecular Formula	C11H16FN2O7P
Molecular Weight	330.23 g/mol
Synonyms	3'-Fluoro-2',3'-didehydro-2',3'-dideoxy-5'-phosphonomethylthymidine; (E)-5-(2-fluoro-2-(phosphonomethoxy)vinyl)uracil; Fd4AP; 1-[(2E)-3-Fluoro-4-(phosphonomethoxy)-2-buten-1-yl]thymine; 3'-Fluoro-2',3'-didehydro-2',3'-dideoxythymidine 5'-phosphonate; Phosphonomethyl PMEA analog; Fluorinated d4T phosphonate; Antiviral nucleotide analog 137248-58-9
EINECS	Contact for details

Quality Control

Our 1-(2',3',5',6'-Tetradeoxy-3'-Fluoro-6'-Phosphono-Erythro-Hexofuranosyl)Thymine is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical research and development. All batches undergo comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with in-house specifications aligned with ICH guidelines. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.