Description

4-Amino-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone is a high-purity nucleoside analogue of significant pharmaceutical importance. This compound serves as a critical chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) for antiviral therapies. It is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of nucleoside-based drugs, particularly for antiviral applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of antiviral nucleoside analogues.
• Antiviral Drug Research: Used in the research and development of novel therapeutic agents targeting viral infections.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of complex, pharmaceutically active molecules.
• Biochemical Research: Utilized in studies involving DNA/RNA synthesis inhibition and enzyme kinetics.
• Process Development & Scale-up: Serves as a reference standard and starting material for process optimization in pilot and commercial-scale manufacturing.

Basic Information

Product Name	4-Amino-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
CAS No.	136891-12-8
Molecular Formula	C8H11N3O3S
Molecular Weight	229.26 g/mol
Synonyms	(-)-2'-Deoxy-3'-thiacytidine; 3TC Intermediate; Lamivudine Intermediate; cis-(-)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; BCH-189 Intermediate; (-)-β-L-2',3'-Dideoxy-3'-thiacytidine; L-(-)-2',3'-Dideoxy-3'-thiacytidine; (2R,5S)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)pyrimidin-2-one
EINECS	Contact for details

Quality Control

Our 4-Amino-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing identity, purity, and specific tests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.